Contraception and Pregnancy in Patients with Rheumatic by Lisa R. Sammaritano, Bonnie L. Bermas

By Lisa R. Sammaritano, Bonnie L. Bermas

Rheumatic (or systemic autoimmune) ailments disproportionately impact younger ladies: the female-to-male ratio for sufferers with systemic lupus erythematosus in the course of the reproductive years is nearly 9:1. within the mid- to late-twentieth century, girls with rheumatic affliction diagnoses have been frequently steered to prevent being pregnant because of worry of illness exacerbation and antagonistic consequence. in additional contemporary years, many girls with rheumatic disorder have deferred childbearing until eventually a later age as a result of lively illness or damaging treatments. even if, with advances in rheumatology remedies, obstetric tracking, and reproductive medication applied sciences, expanding numbers of girls with rheumatic ailments are pursuing being pregnant. consequently, obstetricians and rheumatologists must be conscious of the present nation of data and the options for administration of being pregnant in those sufferers. birth control and being pregnant in sufferers with Rheumatic ailment explains the fundamentals of birth control, fertility therapy, and being pregnant in rheumatic sickness sufferers and serves as a advisor and reference instrument for either rheumatologists and OB/GYNs. so much basic rheumatologists and OB/GYNs have restricted adventure in taking care of rheumatic sickness sufferers while pregnant, and plenty of don't have prepared entry to specialist colleagues during this region. This publication summarizes the present nation of information and provides a basic method for evaluate of the rheumatic affliction sufferer contemplating being pregnant, hormonal birth control or infertility treatment.

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Bermas BL, Hill JA. Proliferative responses to recall antigens are associated with pregnancy outcome in women with a history of recurrent spontaneous abortion. J Clin Invest. 1997;100(6):1330–4. 30. Matthiesen L et al. Lymphocyte subsets and mitogen stimulation of blood lymphocytes in normal pregnancy. Am J Reprod Immunol. 1996;35(2):70–9. 31. Heikkinen J et al. Phenotypic characterization of regulatory T cells in the human decidua. Clin Exp Immunol. 2004;136(2):373–8. J. J. Stephens 32. Jin L-P et al.

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Red-Horse K et al. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest. 2004;114(6):744–54. 47. Veenstra van Nieuwenhoven AL, Heineman MJ, Faas MM. The immunology of successful pregnancy. Hum Reprod Update. 2003;9(4):347–57. 48. Manaster I et al. Endometrial NK cells are special immature cells that await pregnancy. J Immunol. 2008;181(3):1869–76. 49. Male V, et al. Natural killer cells in human pregnancy. In: Campbell KS, editor. Natural killer cell protocols.

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